Bando Jennifer K, Colonna Marco
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Nat Immunol. 2016 Jun 21;17(7):783-9. doi: 10.1038/ni.3484.
Innate lymphoid cells (ILCs) are a family of innate immune cells that have diverse functions during homeostasis and disease. Subsets of ILCs have phenotypes that mirror those of polarized helper T cell subsets in their expression of core transcription factors and effector cytokines. Given the similarities between these two classes of lymphocytes, it is important to understand which functions of ILCs are specialized and which are redundant with those of T cells. Here we discuss genetic mouse models that have been used to delineate the contributions of ILCs versus those of T cells and review the current understanding of the specialized in vivo functions of ILCs.
固有淋巴细胞（ILCs）是一类固有免疫细胞，在体内稳态和疾病过程中具有多种功能。ILCs的亚群在核心转录因子和效应细胞因子的表达上具有与极化辅助性T细胞亚群相似的表型。鉴于这两类淋巴细胞之间的相似性，了解ILCs的哪些功能是特化的，哪些与T细胞的功能冗余很重要。在这里，我们讨论了用于区分ILCs和T细胞作用的基因小鼠模型，并综述了目前对ILCs在体内特化功能的理解。
