Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Children's Health care, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, China.
Sci Rep. 2016 Jun 22;6:28414. doi: 10.1038/srep28414.
To evaluate the characteristics of thyroid carcinoma over time, we carried out a retrospective study to illustrate the evolutionary features of thyroid carcinoma. All records of thyroidectomies from the First Affiliated Hospital of Nanjing Medical University from 2008 to 2013 were obtained focusing on pathological diagnosis, size, local lymph node metastasis (LNM) of the tumors. The thyroid cancer detection rate increased from 24.6% to 41.5% significantly (P < 0.05). Papillary thyroid carcinoma (PTC) remained to be the most common type counting 86.4% of all thyroid carcinomas. In all 1,704 PTCs, microPTC (mPTC) with maximum diameter less than or equal to 10 mm has become the dominant form taking up 56.5% of all PTCs in 2013 while only 43.1% in 2008. The mean maximum tumor size has decreased from 17.8 mm to 12.2 mm significantly (P < 0.05). However, the average age, female dominance, and local LNM remained similarly in the past six years. Logistic regression test showed that the determinants for local LNM were age, gender and tumor size. mPTC has become the most common form of thyroid carcinoma detected during thyroidectomies in China while other features of thyroid carcinoma remained similarly in the recent years.
为了评估甲状腺癌随时间的变化特征，我们进行了一项回顾性研究，以说明甲状腺癌的演变特征。我们从南京医科大学第一附属医院获得了 2008 年至 2013 年所有甲状腺切除术的记录，重点关注病理诊断、肿瘤大小、局部淋巴结转移（LNM）。甲状腺癌的检出率从 24.6%显著增加到 41.5%（P<0.05）。甲状腺乳头状癌（PTC）仍然是最常见的类型，占所有甲状腺癌的 86.4%。在所有 1704 例 PTC 中，最大直径小于或等于 10mm 的微小 PTC（mPTC）已成为 2013 年所有 PTC 的主要形式，占 56.5%，而 2008 年仅为 43.1%。最大肿瘤直径的平均值从 17.8mm 显著下降至 12.2mm（P<0.05）。然而，过去六年中，平均年龄、女性优势和局部 LNM 仍然相似。Logistic 回归检验显示，局部 LNM 的决定因素是年龄、性别和肿瘤大小。mPTC 已成为中国甲状腺切除术检测到的最常见的甲状腺癌形式，而近年来甲状腺癌的其他特征仍然相似。
