Akin Belli Asli, Ozbas Gok Seyran, Akbaba Gulhan, Etgu Fatma, Dogan Gursoy
Department of Dermatology, Kocman University Training and Research Hospital, Mugla.
Department of Dermatology, Artvin Hopa State Hospital, Artvin.
Eur J Dermatol. 2016 Jun 1;26(3):260-4. doi: 10.1684/ejd.2016.2748.
Rosacea is a chronic inflammatory skin disease affecting the face. A positive correlation has been found between rosacea and cardiovascular diseases. We sought to investigate the relation between rosacea and metabolic syndrome (MS) and insulin resistance (IR). Between January and June 2015, a case-control study including 47 age-, gender-, and body mass index (BMI)-matched rosacea patients and 50 controls was conducted. Demographic data, clinical features of rosacea patients, anthropometric measures, laboratory findings, blood pressure levels, BMI, smoking history, alcohol consumption, sports life, family history of cardiovascular disease, and presence of MS and IR were recorded. Forty-seven rosacea patients (12 men and 35 women; age range: 35-68 years) and 50 controls (11 men and 39 women; age range: 38-78 years) were included in our study. Of 47 rosacea patients, 24 had erythematotelangiectatic type, 22 had papulopustular type, and one had phymatous type. Whereas the rate of IR was significantly higher in the rosacea group, there was no significant difference in the rate of MS between rosacea and the control group (p = 0.009 and p = 0.186, respectively). In addition, the rosacea group had significantly higher fasting blood glucose, total cholesterol, and systolic and diastolic blood pressure levels (p<0.05). Mean levels of LDL, triglyceride, total cholesterol and CRP were significantly higher than in the control group (p<0.05). Our findings suggest that there is a relationship between rosacea and IR and some parameters of cardiovascular risk factors. We recommend investigation of IR in rosacea patients.
酒渣鼻是一种影响面部的慢性炎症性皮肤病。酒渣鼻与心血管疾病之间已发现存在正相关关系。我们试图研究酒渣鼻与代谢综合征（MS）及胰岛素抵抗（IR）之间的关系。在2015年1月至6月期间，开展了一项病例对照研究，纳入了47例年龄、性别和体重指数（BMI）匹配的酒渣鼻患者及50例对照。记录了人口统计学数据、酒渣鼻患者的临床特征、人体测量指标、实验室检查结果、血压水平、BMI、吸烟史、饮酒情况、运动生活情况、心血管疾病家族史以及MS和IR的存在情况。我们的研究纳入了47例酒渣鼻患者（12例男性和35例女性；年龄范围：35 - 68岁）和50例对照（11例男性和39例女性；年龄范围：38 - 78岁）。在47例酒渣鼻患者中，24例为红斑毛细血管扩张型，22例为丘疹脓疱型，1例为鼻赘型。虽然酒渣鼻组的IR发生率显著更高，但酒渣鼻组与对照组之间的MS发生率无显著差异（分别为p = 0.009和p = 0.186）。此外，酒渣鼻组的空腹血糖、总胆固醇以及收缩压和舒张压水平显著更高（p<0.05）。低密度脂蛋白、甘油三酯、总胆固醇和C反应蛋白的平均水平显著高于对照组（p<0.05）。我们的研究结果表明酒渣鼻与IR以及心血管危险因素的一些参数之间存在关联。我们建议对酒渣鼻患者进行IR检查。
