Akin Belli Asli, Kara Asude, Ozbas Gok Seyran
Asli Akin Belli, MD, Mugla Sitki Kocman University, Department of Dermatology, 48000, Mugla, Turkey;
Acta Dermatovenerol Croat. 2017 Jul;25(2):145-150.
Recently, diverse hematologic parameters have been used as an indicator of the presence or severity of inflammatory and cardiovascular diseases. Our aim was to investigate the ratios of neutrophils to lymphocytes (NL), monocytes to high-density lipoprotein (HDL) cholesterol (MHC), and platelets to lymphocytes (PL) in patients with rosacea in comparison with the control group and determine whether there was a correlation between these ratios and metabolic disorders in patients with rosacea. We conducted a case-control study on 61 patients with rosacea and 60 healthy controls between January 2015 and January 2016 at the Dermatology Outpatient Clinic, Mugla, Turkey. Demographic data, biochemical parameters, hematologic parameters and ratios, the presence of metabolic syndrome (MS), and the presence of insulin resistance (IR) in the participants were recorded. Sixty one patients with rosacea (16 men, 45 women) and 60 controls (13 men, 47 women) were included in the study. The NL ratio, mean levels of low-density lipoprotein (LDL) and total cholesterol, triglyceride, C-reactive protein (CRP), systolic and diastolic blood pressures, and the presence of IR were significantly higher in patients with rosacea than in controls. In the rosacea group, the MHC ratio was significantly higher in patients with rosacea with IR and MS. Moreover, only the MHC ratio was an independent predictor of MS according to univariate logistic regression analysis. The cutoff value of MHC on admission for predicting MS in patients with rosacea was 0.013.The higher levels of NL ratio and IR in the rosacea group corroborate the previous studies demonstrating a high level of cardiovascular risk factors in patients with rosacea. The MHC ratio may be used as a simple and inexpensive method to predict metabolic disorders in patients with rosacea.
最近，多种血液学参数已被用作炎症和心血管疾病存在或严重程度的指标。我们的目的是研究酒渣鼻患者与对照组相比，中性粒细胞与淋巴细胞的比率（NL）、单核细胞与高密度脂蛋白（HDL）胆固醇的比率（MHC）以及血小板与淋巴细胞的比率（PL），并确定这些比率与酒渣鼻患者代谢紊乱之间是否存在相关性。2015年1月至2016年1月期间，我们在土耳其穆拉的皮肤科门诊对61例酒渣鼻患者和60例健康对照者进行了一项病例对照研究。记录了参与者的人口统计学数据、生化参数、血液学参数和比率、代谢综合征（MS）的存在情况以及胰岛素抵抗（IR）的存在情况。该研究纳入了61例酒渣鼻患者（16例男性，45例女性）和60例对照者（13例男性，47例女性）。酒渣鼻患者的NL比率、低密度脂蛋白（LDL）和总胆固醇的平均水平、甘油三酯、C反应蛋白（CRP）、收缩压和舒张压以及IR的存在情况均显著高于对照组。在酒渣鼻组中，患有IR和MS的酒渣鼻患者的MHC比率显著更高。此外，根据单因素逻辑回归分析，只有MHC比率是MS的独立预测指标。酒渣鼻患者入院时预测MS的MHC临界值为0.013。酒渣鼻组中较高的NL比率和IR水平证实了先前的研究，这些研究表明酒渣鼻患者存在高水平的心血管危险因素。MHC比率可作为一种简单且廉价的方法来预测酒渣鼻患者的代谢紊乱。
