Shi Lei, Luo Min, Chen Wei R, Hu Chan, Zhang Guolong, Zhang Fuhe, Chen Jia, Mo Xiaohui, Cai Qing, Yang Lianjuan, Wang Xiuli
Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, P. R. China.
Biophotonics Research Laboratory, Center for Interdisciplinary Biomedical Education and Research, University of Central Oklahoma, Edmond, Oklahoma, USA.
Dermatol Ther. 2016 Sep;29(5):353-357. doi: 10.1111/dth.12376. Epub 2016 Jun 21.
Cutaneous granulomas caused by Candida guilliermondii are difficult to cure. In situ photoimmunotherapy (ISPI) is a novel method composed of local photothermal therapy and immunoadjuvant. In this study, ISPI was used the first time clinically for cutaneous granuloma caused by itraconazole-resistant C.guilliermondii. A 10-week cycle of ISPI was composed of (1) 5% imiquimod applied topically every other day and (2) irradiation of lesions with an 808-nm diode laser at Days 14, 28, 42, and 56. Here we report our first case. A patient was treated with ISPI for four cycles. After the treatment, the lesions were eliminated without recurrence during a 12-month follow-up. Our results demonstrate that ISPI can be used as an effective treatment modality for cutaneous fungal granuloma.
季也蒙念珠菌引起的皮肤肉芽肿难以治愈。原位光免疫疗法（ISPI）是一种由局部光热疗法和免疫佐剂组成的新方法。在本研究中，ISPI首次在临床上用于治疗对伊曲康唑耐药的季也蒙念珠菌引起的皮肤肉芽肿。一个为期10周的ISPI疗程包括：（1）每隔一天局部外用5%咪喹莫特；（2）在第14、28、42和56天用808纳米二极管激光照射皮损。在此我们报告首例病例。一名患者接受了四个疗程的ISPI治疗。治疗后，皮损消退，在12个月的随访期间无复发。我们的结果表明，ISPI可作为皮肤真菌性肉芽肿的一种有效治疗方式。
