Yang Heli, Xu Xiaoxi, Ran Xin, Ran Yuping
Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China.
Dermatol Ther (Heidelb). 2020 Aug;10(4):847-853. doi: 10.1007/s13555-020-00384-w. Epub 2020 May 14.
Candidal granuloma is a rare and refractory disease in clinical practice, usually reported in immunocompromised patients. We report a 57-year-old man who presented with candidal granuloma caused by Candida tropicalis. The diagnosis was confirmed according to histopathology and molecular identification. Prolonged duration of initial antifungal therapy did not obtain satisfactory improvement. Finally, the refractory disease was successfully treated by itraconazole and terbinafine in combination with hyperthermia and cryotherapy. The "blackish-red dot" dermoscopic sign of the verrucous granuloma gradually resolved during the treatment.
念珠菌性肉芽肿在临床实践中是一种罕见且难治的疾病，通常见于免疫功能低下的患者。我们报告一名57岁男性，其患有热带念珠菌引起的念珠菌性肉芽肿。根据组织病理学和分子鉴定确诊。初始抗真菌治疗疗程延长未取得满意的改善效果。最终，通过伊曲康唑和特比萘芬联合热疗和冷冻疗法成功治疗了这种难治性疾病。疣状肉芽肿的“黑红色斑点”皮肤镜表现在治疗过程中逐渐消退。
