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Metacycloprodigiosin induced cell death selectively in β-catenin-mutated tumor cells.

作者信息

Ikeda Hiroaki, Shikata Yuki, Watanapokasin Ramida, Tashiro Etsu, Imoto Masaya

机构信息

Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama, Japan.

Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand.

出版信息

J Antibiot (Tokyo). 2017 Jan;70(1):109-112. doi: 10.1038/ja.2016.75. Epub 2016 Jun 22.

DOI:10.1038/ja.2016.75
PMID:27328865
Abstract
摘要

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本文引用的文献

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SMK-17, a MEK1/2-specific inhibitor, selectively induces apoptosis in β-catenin-mutated tumors.SMK-17是一种MEK1/2特异性抑制剂，可选择性地诱导β-连环蛋白突变肿瘤细胞凋亡。
Sci Rep. 2015 Feb 2;5:8155. doi: 10.1038/srep08155.
2
WNT signalling pathways as therapeutic targets in cancer.WNT 信号通路作为癌症的治疗靶点。
Nat Rev Cancer. 2013 Jan;13(1):11-26. doi: 10.1038/nrc3419.
3
The β-catenin destruction complex.β-连环蛋白降解复合物。
通过低成本诱导策略提高海洋内生重组菌株 Streptomyces sp.ALAA-R20 中灵菌红素的产量。
J Appl Genet. 2021 Feb;62(1):165-182. doi: 10.1007/s13353-020-00597-x. Epub 2021 Jan 7.
4
Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells.线粒体解偶联剂对β-连环蛋白突变肿瘤细胞具有合成致死效应。
Cancer Sci. 2017 Apr;108(4):772-784. doi: 10.1111/cas.13172.
Cold Spring Harb Perspect Biol. 2013 Jan 1;5(1):a007898. doi: 10.1101/cshperspect.a007898.
4
Small molecule-based promotion of PKCα-mediated β-catenin degradation suppresses the proliferation of CRT-positive cancer cells.基于小分子的 PKCα 介导的 β-连环蛋白降解促进剂抑制 CRT 阳性癌细胞的增殖。
PLoS One. 2012;7(10):e46697. doi: 10.1371/journal.pone.0046697. Epub 2012 Oct 5.
5
Vacuolar H+-ATPase inhibitors overcome Bcl-xL-mediated chemoresistance through restoration of a caspase-independent apoptotic pathway.液泡H⁺-ATP酶抑制剂通过恢复非半胱天冬酶依赖性凋亡途径克服Bcl-xL介导的化疗耐药性。
Cancer Sci. 2009 Aug;100(8):1460-7. doi: 10.1111/j.1349-7006.2009.01194.x. Epub 2009 May 13.
6
Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology.液泡型ATP酶：生理与病理生理学中的旋转质子泵
Nat Rev Mol Cell Biol. 2007 Nov;8(11):917-29. doi: 10.1038/nrm2272.
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Tumor acidity, chemoresistance and proton pump inhibitors.肿瘤酸度、化疗耐药性与质子泵抑制剂
Future Oncol. 2005 Dec;1(6):779-86. doi: 10.2217/14796694.1.6.779.
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Cell. 2002 Mar 22;108(6):837-47. doi: 10.1016/s0092-8674(02)00685-2.
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Wnt signaling and cancer.Wnt信号传导与癌症。
Genes Dev. 2000 Aug 1;14(15):1837-51.