来自海绵源放线菌新种糖多孢菌属的间环原放线菌素和十一烷基原放线菌素的高效体外抗癌活性
Potent in vitro anticancer activity of metacycloprodigiosin and undecylprodigiosin from a sponge-derived actinomycete Saccharopolyspora sp. nov.
作者信息
Liu Rui, Cui Cheng-Bin, Duan Lin, Gu Qian-Qun, Zhu Wei-Ming
机构信息
Key Laboratory of Marine Drugs, Chinese Ministry of Education, PR China.
出版信息
Arch Pharm Res. 2005 Dec;28(12):1341-4. doi: 10.1007/BF02977899.
Bioassay-guided fractionation of CHCl3 extract from the fermentation broth of a sponge Mycale plumose-derived actinomycete Saccharopolyspora sp. nov., led to the isolation of two known prodigiosin analogs--metacycloprodigiosin (1) and undecylprodigiosin (2). These compounds exhibited significant cytotoxic activities against five cancer cell lines: P388, HL60, A-549, BEL-7402, and SPCA4. This is the first report on the significant cytotoxicity of metacycloprodigiosin (1) against human cancer cell lines.
对源自海绵状羽毛裸鳃亚目放线菌新种糖多孢菌的发酵液的氯仿提取物进行生物测定导向的分级分离，得到了两种已知的灵菌红素类似物——间环灵菌红素（1）和十一烷基灵菌红素（2）。这些化合物对五种癌细胞系：P388、HL60、A-549、BEL-7402和SPCA4表现出显著的细胞毒性活性。这是关于间环灵菌红素（1）对人癌细胞系具有显著细胞毒性的首次报道。
Zotero 插件