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肿瘤组织和无肿瘤人体组织中铬和镍的定量测定。

Quantitative determination of chromium and nickel in tumour and tumour-free human tissue.

作者信息

Raithel H J, Hennig F, Schaller K H

机构信息

Institute of Occupational and Social Medicine, University of Erlangen-Nuremberg, FRG.

出版信息

J Environ Pathol Toxicol Oncol. 1989 Mar-Apr;9(2):115-26.

PMID:2732907
Abstract

Environmental pollution with carcinogenic substances, in addition to individual abuse, are discussed as important factors causing development of cancer. We must assume that certain nickel and chromium compounds, which are ubiquitous in our ecosystem, must have carcinogenic effects on humans too. The aim of this study is therefore to examine the extent to which the accumulation of the potentially carcinogenic metal ions nickel and chromium could be measured in tissue from tumour patients. We examined tumour and tumour-free tissue obtained from a total of 48 patients who had carcinomas of the stomach, bowel, or kidney. We also analyzed nickel and chromium content in whole blood and urine samples from these persons. The quantitative metal estimations were done using atomic absorption spectrophotometry. Differences between chromium and/or nickel content in tumour or tumour-free tissue were not observed. An accumulation of these metal ions in tumour tissue is therefore improbable. We were also unable to find differences in metal content with regard to chromium and nickel as related to the appearance of tumour in the organ. In contrast, tumour patients had a 5- to 7-fold increase over normal values for chromium and nickel in blood and urine. This was attributable to unavoidable contamination of tissue and body fluids with chromium- and nickel-containing instruments during major surgical procedures.

摘要

除个人滥用外,具有致癌性物质的环境污染被认为是导致癌症发生的重要因素。我们必须假定,在我们的生态系统中普遍存在的某些镍和铬化合物,对人类也一定具有致癌作用。因此,本研究的目的是检测在肿瘤患者的组织中能够检测到潜在致癌金属离子镍和铬积累的程度。我们检查了总共48例患有胃癌、肠癌或肾癌患者的肿瘤组织和非肿瘤组织。我们还分析了这些人的全血和尿液样本中的镍和铬含量。使用原子吸收分光光度法进行金属定量测定。未观察到肿瘤组织或非肿瘤组织中铬和/或镍含量的差异。因此,这些金属离子在肿瘤组织中积累的可能性不大。我们也未能发现与器官中肿瘤出现相关的铬和镍的金属含量差异。相比之下,肿瘤患者血液和尿液中的铬和镍含量比正常值高出5至7倍。这归因于在大手术过程中,组织和体液不可避免地被含铬和镍的器械污染。

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