Kuo Chung-Yih, Wong Ruey-Hong, Lin Jia-Yi, Lai Ji-Ching, Lee Huei
Department of Public Health, College of Health Care and Management, Chung Shan Medical University, Taichung, Taiwan, Republic of China.
J Toxicol Environ Health A. 2006 Jul;69(14):1337-44. doi: 10.1080/15287390500360398.
Metallic carcinogenicity is generally thought to generate of free radicals, and thus some metals were reported to play a role in lung tumorigenesis. In order to verify the role of heavy metals in the development of Taiwanese lung cancer, a case-control study was conducted to compare heavy metal contents between 60 tumor and 42 normal lung tissues surgically resected from lung cancer and noncancer patients. The tissue concentration of heavy metals, including cadmium (Cd), chromium (Cr), cobalt (Co), lead (Pb), and nickel (Ni), was measured using by atomic absorption spectrometry (AAS). Our results indicated that Cr and Ni contents in lung tumors of lung cancer patients were significantly higher than those in normal lung tissue of noncancer controls, but Co content was markedly lower in lung tumors. Additionally, Pb content in lung tumors was associated with nodal involvement, and Co amounts in squamous-cell carcinomas were relatively higher than those in adenocarcinomas. Data suggest that accumulation of Cr and Ni in lung tumors may play a role, at least in part, in the development of lung cancer in Taiwan.
金属致癌性通常被认为会产生自由基，因此有报道称某些金属在肺癌发生过程中起作用。为了验证重金属在台湾肺癌发生中的作用，进行了一项病例对照研究，比较了从肺癌患者和非癌症患者手术切除的60个肿瘤肺组织和42个正常肺组织中的重金属含量。使用原子吸收光谱法（AAS）测量了包括镉（Cd）、铬（Cr）、钴（Co）、铅（Pb）和镍（Ni）在内的重金属的组织浓度。我们的结果表明，肺癌患者肺肿瘤中的Cr和Ni含量显著高于非癌症对照的正常肺组织，但肺肿瘤中的Co含量明显较低。此外，肺肿瘤中的Pb含量与淋巴结受累有关，鳞状细胞癌中的Co含量相对高于腺癌。数据表明，肺肿瘤中Cr和Ni的积累可能至少在一定程度上在台湾肺癌的发生中起作用。
