Chirila T V, Constable I J, Russo A V, Linton R G
Lions Eye Institute, Perth, Western Australia.
J Cataract Refract Surg. 1989 May;15(3):283-8. doi: 10.1016/s0886-3350(89)80085-9.
Two original Ridley intraocular lenses, made of poly(methyl methacrylate) (PMMA) at least 35 years ago, were extracted in two different media, diethyl ether and water. The extracts were suitably processed and analyzed by high resolution capillary gas chromatography. Residual monomer (MMA) was detected in both extracts. The amount of MMA in the aqueous extract was significantly lower than that in the ether extract. It is postulated that the residual monomer in lenses originated from an incomplete polymerization at the time of the polymer production. However, the MMA content found in one lens (0.147%) is comparable to that currently detected in modern IOLs, and probably does not cause toxic reaction in the eye because it is leached out by aqueous fluid action to a very low extent.
两枚至少在35年前制造的、由聚甲基丙烯酸甲酯（PMMA）制成的原装里德利人工晶状体，在两种不同介质——乙醚和水中进行了提取。提取物经过适当处理后，采用高分辨率毛细管气相色谱法进行分析。在两种提取物中均检测到了残留单体（MMA）。水提取物中的MMA含量显著低于乙醚提取物中的含量。据推测，晶状体中的残留单体源于聚合物生产时的不完全聚合。然而，在一枚晶状体中发现的MMA含量（0.147%）与目前在现代人工晶状体中检测到的含量相当，并且由于其在房水作用下的浸出程度非常低，可能不会在眼中引起毒性反应。
