Chen Yanqiu, Zhou Lifeng, Yang Yan
Guangzhou Medical College, Guangzhou Women and Children's Medical Center, Department of Otolaryngology, Guangzhou, China.
Guangzhou Medical College, Guangzhou Women and Children's Medical Center, Department of Otolaryngology, Guangzhou, China.
Braz J Otorhinolaryngol. 2017 Mar-Apr;83(2):190-194. doi: 10.1016/j.bjorl.2016.03.006. Epub 2016 Apr 22.
The role of platelet activation in allergic inflammation is receiving increasing attention. Sublingual immunotherapy for allergic rhinitis can modify the immunological process to an allergen, rather than simply treating symptoms.
The aim of this study was to explore the role of platelet activation during sublingual immunotherapy in children with allergic rhinitis.
Forty-two House Dust Mite - sensitized children with allergic rhinitis were enrolled and received House Dust Mite allergen extract for sublingual immunotherapy or placebo. Serum of different time points during treatment was collected and used for detection of Platelet Factor-4 and Beta-Thromboglobulin concentration by Enzyme-Linked Immuno Sorbent Assay.
Our data showed decreased expression of Platelet Factor-4 and Beta-Thromboglobulin protein after one year's sublingual immunotherapy. In addition, the decrease of symptom scores and serum Platelet Factor-4 and Beta-Thromboglobulin protein concentrations was positively related.
During sublingual immunotherapy, platelet activation was inhibited significantly. Our results might indicate that inhibition of platelet activation within the systemic circulation is an important mechanism during sublingual immunotherapy.
血小板活化在变应性炎症中的作用日益受到关注。变应性鼻炎的舌下免疫疗法可改变针对变应原的免疫过程，而非仅仅治疗症状。
本研究旨在探讨血小板活化在变应性鼻炎儿童舌下免疫疗法中的作用。
纳入42例对屋尘螨致敏的变应性鼻炎儿童，给予屋尘螨变应原提取物进行舌下免疫疗法或安慰剂治疗。收集治疗期间不同时间点的血清，采用酶联免疫吸附测定法检测血小板因子4和β-血小板球蛋白浓度。
我们的数据显示，经过一年的舌下免疫疗法后，血小板因子4和β-血小板球蛋白蛋白表达降低。此外，症状评分的降低与血清血小板因子4和β-血小板球蛋白蛋白浓度的降低呈正相关。
在舌下免疫疗法期间，血小板活化受到显著抑制。我们的结果可能表明，抑制全身循环中的血小板活化是舌下免疫疗法的重要机制。
