Sheppard S, Nevin N C, Seller M J, Wild J, Smithells R W, Read A P, Harris R, Fielding D W, Schorah C J
Department of Paediatrics and Child Health, University of Leeds.
J Med Genet. 1989 May;26(5):326-9. doi: 10.1136/jmg.26.5.326.
A total of 227 mothers enrolled for periconceptional multivitamin supplementation because of previous neural tube defect (NTD) births took vitamins for less than the recommended minimum period (at least 28 days before conception until two menstrual periods have been missed). Of 213 examined infants/fetuses born to these partially supplemented mothers, two had NTD, one of whom followed four previous NTDs. The observed NTD recurrence rate is similar to that observed in fully supplemented mothers. A further 14 mothers started supplements before the second missed period but after the normal time of neural tube closure. Three of their offspring had NTD. The significance of this apparently high recurrence rate is discussed.
共有227名因之前生育过神经管缺陷（NTD）患儿而登记进行围孕期多种维生素补充的母亲，服用维生素的时间少于推荐的最短期限（受孕前至少28天直至错过两个月经期）。在这些部分补充维生素的母亲所生育的213名接受检查的婴儿/胎儿中，有2例患有NTD，其中1例之前已有4次NTD生育史。观察到的NTD复发率与完全补充维生素的母亲中观察到的复发率相似。另有14名母亲在错过第二个月经期之前但在神经管正常闭合时间之后开始补充维生素。她们的3名后代患有NTD。本文讨论了这一明显较高复发率的意义。
