Maggi C A, Barbanti G, Santicioli P, Beneforti P, Misuri D, Meli A, Turini D
Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.
J Urol. 1989 Jul;142(1):150-4. doi: 10.1016/s0022-5347(17)38701-3.
Intravesical instillation of capsaicin (0.1 to 10 microM) in six patients (five with hypersensitive disorders of the lower urinary tract, one with benign prostatic hyperplasia) produced a concentration-related reduction of the first desire to void, bladder capacity and pressure threshold for micturition. At a threshold concentration of one microM, capsaicin also produced a warm to burning sensation referred to the suprapubic area during the collecting phase and to the urethra during micturition. All the patients with hypersensitive disorders of the lower urinary tract reported disappearance or marked attenuation of their symptoms for a few days after capsaicin application. In three other patients with hypersensitive disorders of the lower urinary tract, intravesical instillation of capsaicin's vehicle (0.1% ethanol in saline) did not produce significant cystometric changes nor modify the symptomatology. These observations provide the first indication that capsaicin-sensitive structures (nerves?) may be present in the human urinary bladder as they have been shown to occur in various other species.
对6例患者（5例患有下尿路过敏症，1例患有良性前列腺增生）膀胱内灌注辣椒素（0.1至10微摩尔）后，首次排尿欲望、膀胱容量和排尿压力阈值均出现与浓度相关的降低。在1微摩尔的阈值浓度下，辣椒素在收集期会使耻骨上区域产生温热至灼烧感，排尿时则使尿道产生这种感觉。所有患有下尿路过敏症的患者在应用辣椒素后几天均报告症状消失或明显减轻。在另外3例患有下尿路过敏症的患者中，膀胱内灌注辣椒素的赋形剂（盐水中0.1%的乙醇）未产生明显的膀胱测压变化，也未改变症状。这些观察结果首次表明，人膀胱中可能存在对辣椒素敏感的结构（神经？），正如在其他各种物种中所显示的那样。
