Yasuda S, Sumi H, Masuda J, Sekiguchi H, Nagano M, Morishige H, Minamitani H
Masui. 1989 Feb;38(2):177-81.
In this study, we have examined the availability of catheter tip type transducer for the partitioning of respiratory impedance. Total respiratory resistance and reactance from 1 to 20 Hz determined by forced oscillation method with random noise input in anesthetized dogs were partitioned by catheter tip type transducer into central airway resistance (Rc) and reactance (Xc) as well as peripheral resistance (Rp) and reactance (Xp). Intratracheal acetylcholine (0.1g) increased Rp at the wide frequency range (from about 1 to 20 Hz), although Rc did not change with it. The decreases of Rc at higher frequencies (over 12Hz) were produced by intratracheal salbutamol (10mg), whereas Rp did not change significantly. These results suggest that the predominant site of action of intratracheal acetylcholine and salbutamol is peripheral airway and central airway respectively. We have concluded that the respiratory impedance can be partitioned noninvasively with catheter tip type transducer without pneumothorax and hemorrhage caused with the retrograde catheter. This method can be applied clinically during general anesthesia or in intensive care.
在本研究中，我们研究了导管尖端型换能器用于呼吸阻抗分区的可行性。在麻醉犬中，通过随机噪声输入的强迫振荡法测定的1至20Hz的总呼吸阻力和电抗，用导管尖端型换能器分为中央气道阻力（Rc）和电抗（Xc）以及外周阻力（Rp）和电抗（Xp）。气管内注射乙酰胆碱（0.1g）在较宽频率范围（约1至20Hz）增加了Rp，而Rc并未随之改变。气管内注射沙丁胺醇（10mg）使较高频率（超过12Hz）的Rc降低，而Rp没有明显变化。这些结果表明，气管内乙酰胆碱和沙丁胺醇的主要作用部位分别是外周气道和中央气道。我们得出结论，使用导管尖端型换能器可以在无逆行导管引起的气胸和出血的情况下无创地对呼吸阻抗进行分区。该方法可在全身麻醉期间或重症监护中临床应用。
