足部电击对大鼠口服硝酸异山梨酯药代动力学的影响。
Influence of electric foot shock on pharmacokinetics of isosorbide dinitrate orally administered to rats.
作者信息
Gomita Y, Furuno K, Araki Y
机构信息
Department of Hospital Pharmacy, Okayama University Medical School, Japan.
出版信息
Jpn J Pharmacol. 1989 Feb;49(2):297-9. doi: 10.1254/jjp.49.297.
PMID:2733266
Abstract
The influence of emotional stress on the pharmacokinetics of isosorbide dinitrate (ISDN) was studied in rats. Plasma levels of orally administered ISDN and metabolites (5-isosorbide mononitrate and 2-isosorbide mononitrate) were lower in rats emotionally stressed by foot shock than in non-stressed control rats. The decrease in the ISDN levels may be mainly due to the delay of drug absorption from the gastrointestinal tract.
摘要
在大鼠中研究了情绪应激对硝酸异山梨酯（ISDN）药代动力学的影响。通过足部电击造成情绪应激的大鼠口服ISDN及其代谢产物（5-单硝酸异山梨酯和2-单硝酸异山梨酯）的血浆水平低于未应激的对照大鼠。ISDN水平的降低可能主要是由于药物从胃肠道吸收延迟所致。
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