电足部电击对皮下给予大鼠的硝酸异山梨酯药代动力学的影响。

Influence of electric foot shock on pharmacokinetics of isosorbide dinitrate subcutaneously administered to rats.

作者信息

Gomita Y, Furuno K, Araki Y

机构信息

Department of Hospital Pharmacy, Okayama University Medical School, Japan.

出版信息

Jpn J Pharmacol. 1989 Sep;51(1):132-5. doi: 10.1254/jjp.51.132.

DOI:10.1254/jjp.51.132

PMID:2810934

Abstract

The influence of emotional stress on the pharmacokinetics of isosorbide dinitrate (ISDN) administered s.c. to rats was studied. The plasma level of ISDN in emotionally stressed (ES) rats was the same as that in non-stressed control rats. However, the levels of its metabolites, 5-isosorbide mononitrate (5-ISMN) and 2-isosorbide mononitrate (2-ISMN), were markedly lower in ES rats than in the control rats. On the other hand, urine ISDN and 2-ISMN excretion rates were lower in ES rats than in the control rats. These observations suggest that the pharmacokinetics of ISDN administered s.c. is influenced by emotional stress such as foot shock.

摘要

研究了情绪应激对皮下注射于大鼠的硝酸异山梨酯（ISDN）药代动力学的影响。情绪应激（ES）大鼠的ISDN血浆水平与非应激对照大鼠相同。然而，其代谢产物5-单硝酸异山梨酯（5-ISMN）和2-单硝酸异山梨酯（2-ISMN）的水平在ES大鼠中明显低于对照大鼠。另一方面，ES大鼠的尿液ISDN和2-ISMN排泄率低于对照大鼠。这些观察结果表明，皮下注射ISDN的药代动力学受足部电击等情绪应激的影响。