情绪应激对腹腔注射给大鼠的硝酸异山梨酯药代动力学的影响。
Influence of emotional stress on pharmacokinetics of isosorbide dinitrate intraperitoneally administered to rats.
作者信息
Gomita Y, Furuno K, Araki Y
机构信息
Department of Hospital Pharmacy, Okayama University Medical School, Japan.
出版信息
Acta Med Okayama. 1990 Feb;44(1):51-3. doi: 10.18926/AMO/30468.
PMID:2330846
Abstract
The plasma level of isosorbide dinitrate intraperitoneally administered to rats stressed by foot-shock was almost the same as that in non-stressed control rats. However, levels of its metabolites, 5-isosorbide mononitrate and 2-isosorbide mononitrate, were lower in stressed rats than in non-stressed rats, suggesting that stress may influence the metabolism and/or excretion of the metabolites.
摘要
腹腔注射异山梨醇二硝酸酯的大鼠在遭受足部电击应激后，其血浆水平与未应激的对照大鼠几乎相同。然而，应激大鼠体内其代谢产物5-异山梨醇单硝酸酯和2-异山梨醇单硝酸酯的水平低于未应激大鼠，这表明应激可能会影响代谢产物的代谢和/或排泄。
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