三维细胞载体内微流控网络的原位图案化。
In Situ Patterning of Microfluidic Networks in 3D Cell-Laden Hydrogels.
机构信息
Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
Institute of Chemical Sciences and Engineering, School of Basic Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
出版信息
Adv Mater. 2016 Sep;28(34):7450-6. doi: 10.1002/adma.201601099. Epub 2016 Jun 23.
Focalized short-pulsed lasers have sufficient power to generate micrometer-sized cavities in various hydrogels. An in situ technique based on laser ablation to fabricate intricate microfluidic networks in biocompatible gels without manual handling is presented. This method is fully compatible with 3D cell culture and opens up unprecedented opportunities for cell biology, developmental biology, and stem-cell-based tissue engineering.
聚焦短脉冲激光器具有足够的功率，可以在各种水凝胶中产生微米级的空穴。本文提出了一种基于激光烧蚀的原位技术，可在无需人工处理的情况下，在生物相容性凝胶中制造复杂的微流控网络。该方法完全兼容 3D 细胞培养，为细胞生物学、发育生物学和基于干细胞的组织工程学带来了前所未有的机遇。
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