Li Wei, Li Jinhua, Pan Chen, Lee Jae-Seong, Kim Byoung Soo, Gao Ge
School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.
School of Medical Technology, Beijing Institute of Technology, Zhengzhou Academy of Intelligent Technology, Zhengzhou 450000, China.
Mater Today Bio. 2024 Oct 2;29:101286. doi: 10.1016/j.mtbio.2024.101286. eCollection 2024 Dec.
Vascular tissue engineering faces significant challenges in creating vascular disease models, implantable vascular grafts, and vascularized tissue/organ constructs due to limitations in manufacturing precision, structural complexity, replicating the composited architecture, and mimicking the mechanical properties of natural vessels. Light-based 3D bioprinting, leveraging the unique advantages of light including high resolution, rapid curing, multi-material adaptability, and tunable photochemistry, offers transformative solutions to these obstacles. With the emergence of diverse light-based 3D bioprinting techniques and innovative strategies, the advances in vascular tissue engineering have been significantly accelerated. This review provides an overview of the human vascular system and its physiological functions, followed by an in-depth discussion of advancements in light-based 3D bioprinting, including light-dominated and light-assisted techniques. We explore the application of these technologies in vascular tissue engineering for creating vascular disease models recapitulating key pathological features, implantable blood vessel grafts, and tissue analogs with the integration of capillary-like vasculatures. Finally, we provide readers with insights into the future perspectives of light-based 3D bioprinting to revolutionize vascular tissue engineering.
由于在制造精度、结构复杂性、复制复合结构以及模拟天然血管的机械性能方面存在局限性，血管组织工程在创建血管疾病模型、可植入血管移植物以及血管化组织/器官构建体方面面临重大挑战。基于光的3D生物打印利用了光的独特优势，包括高分辨率、快速固化、多材料适应性和可调光化学性质，为这些障碍提供了变革性的解决方案。随着各种基于光的3D生物打印技术和创新策略的出现，血管组织工程的进展得到了显著加速。本综述概述了人体血管系统及其生理功能，随后深入讨论了基于光的3D生物打印的进展，包括光主导和光辅助技术。我们探讨了这些技术在血管组织工程中的应用，用于创建再现关键病理特征的血管疾病模型、可植入血管移植物以及整合了毛细血管样脉管系统的组织类似物。最后，我们为读者提供了基于光的3D生物打印在革新血管组织工程方面的未来展望。
