德国温血种公马精液质量性状的全基因组关联研究。
Genome-wide association study for semen quality traits in German Warmblood stallions.
作者信息
Gottschalk Maren, Metzger Julia, Martinsson Gunilla, Sieme Harald, Distl Ottmar
机构信息
Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover (Foundation), Hannover, Germany.
State Stud Celle of Lower Saxony, Spörckenstraße 10, 29221 Celle, Germany.
出版信息
Anim Reprod Sci. 2016 Aug;171:81-6. doi: 10.1016/j.anireprosci.2016.06.002. Epub 2016 Jun 8.
We performed a genome-wide association study for semen quality traits in 139 German Warmblood stallions. Stallions were genotyped using the Illumina equine SNP50 Beadchip. Traits analysed were de-regressed estimated breeding values (EBVs) for gel-free volume, sperm concentration, total number of sperm, progressive motility and the total number of progressively motile sperm. The GWAS revealed 29 SNPs on 12 different chromosomes as genome-wide significantly associated with semen quality traits. For ten genomic regions we could retrieve candidate genes influencing stallion fertility. Among the candidate genes, we could find the genes encoding cysteine-rich secretory proteins (CRISP1, CRISP2 and CRISP3). This was the first GWAS in horses performed for semen quality traits.
我们对139匹德国温血种公马的精液质量性状进行了全基因组关联研究。使用Illumina马SNP50芯片对种公马进行基因分型。分析的性状为去回归估计育种值（EBV），包括无凝胶体积、精子浓度、精子总数、前向运动性以及前向运动精子总数。全基因组关联研究揭示了12条不同染色体上的29个单核苷酸多态性（SNP）与精液质量性状在全基因组水平上显著相关。对于10个基因组区域，我们能够检索到影响种公马生育力的候选基因。在候选基因中，我们发现了编码富含半胱氨酸分泌蛋白的基因（CRISP1、CRISP2和CRISP3）。这是首次针对精液质量性状在马匹中进行的全基因组关联研究。
Zotero 插件