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在单个微流控装置中通过双乳液法将 PDMS 改性以制备 PLGA 微球。

Modification of PDMS to fabricate PLGA microparticles by a double emulsion method in a single microfluidic device.

机构信息

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

National Cell Bank, Pasteur Institute of Iran, Tehran, Iran.

出版信息

Lab Chip. 2016 Jul 5;16(14):2596-600. doi: 10.1039/c6lc00437g.

DOI:10.1039/c6lc00437g
PMID:27334791
Abstract

We present an easy, durable method to generate a partially hydrophilic/hydrophobic poly(dimethylsiloxane) (PDMS) microfluidic device. The functionality of this device was assessed in a double flow focusing design to fabricate core-shell structured poly(lactic-co-glycolic acid) (PLGA) microparticles (MPs).

摘要

我们提出了一种简单、耐用的方法来制备部分亲水/疏水的聚二甲基硅氧烷（PDMS）微流控器件。该器件的功能通过双流动聚焦设计进行评估，以制备核壳结构的聚乳酸-共-羟基乙酸（PLGA）微球（MPs）。

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