Li Qiang, Li Teng, Cao Xiang-Chang, Luo De-Qing, Lian Ke-Jian
The Affiliated Dongnan Hospital of Xiamen University, Zhangzhou, Fujian Province, China.
Neural Regen Res. 2016 May;11(5):835-41. doi: 10.4103/1673-5374.182713.
Corticosteroids are widely used for the treatment of acute central nervous system injury. However, their bioactivity is limited by their short half-life. Sustained release of glucocorticoids can prolong their efficacy and inhibit scar formation at the site of nerve injury. In the present study, we wrapped the anastomotic ends of the rat sciatic nerve with a methylprednisolone sustained-release membrane. Compared with methylprednisone alone or methylprednisone microspheres, the methylprednisolone microsphere sustained-release membrane reduced tissue adhesion and inhibited scar tissue formation at the site of anastomosis. It also increased sciatic nerve function index and the thickness of the myelin sheath. Our findings show that the methylprednisolone microsphere sustained-release membrane effectively inhibits scar formation at the site of anastomosis of the peripheral nerve, thereby promoting nerve regeneration.
皮质类固醇广泛用于治疗急性中枢神经系统损伤。然而，它们的生物活性受到其短半衰期的限制。糖皮质激素的持续释放可以延长其疗效并抑制神经损伤部位的瘢痕形成。在本研究中，我们用甲基强的松龙缓释膜包裹大鼠坐骨神经的吻合端。与单独使用甲基强的松龙或甲基强的松龙微球相比，甲基强的松龙微球缓释膜减少了组织粘连并抑制了吻合部位的瘢痕组织形成。它还增加了坐骨神经功能指数和髓鞘厚度。我们的研究结果表明，甲基强的松龙微球缓释膜有效抑制周围神经吻合部位的瘢痕形成，从而促进神经再生。
