Lozada Luis E, Nylund Cade M, Gorman Gregory H, Hisle-Gorman Elizabeth, Erdie-Lalena Christine R, Kuehn Devon
Walter Reed National Military Medical Center, Bethesda, MD, USA; Uniformed Services University of Health Sciences, Bethesda, MD, USA.
Uniformed Services University of Health Sciences, Bethesda, MD, USA.
Glob Pediatr Health. 2015 Jul 21;2:2333794X15596518. doi: 10.1177/2333794X15596518. eCollection 2015.
Autism spectrum disorders (ASD) are a common neurodevelopmental disorder of unknown etiology. Studies suggest a link between autism and neonatal jaundice. A 1:3 matched case-control study was conducted with children enrolled in the Military Health System born between October 2002 and September 2009. Diagnostic and procedure codes were used for identifying ASD and hyperbilirubinemia. Two definitions for hyperbilirubinemia were evaluated: an inpatient admission with a diagnosis of jaundice and treatment with phototherapy. A total of 2917 children with ASD and 8751 matched controls were included in the study. After adjustment, there remained an association between ASD in children and an admission with a diagnosis of jaundice (odds ratio = 1.18; 95% confidence interval = 1.06-1.31; P = .001) and phototherapy treatment (odds ratio = 1.33; 95% confidence interval = 1.04-1.69; P = .008). Children who develop ASD are more likely to have an admission with a diagnosis of jaundice in the neonatal period and more likely to require treatment for this jaundice.
自闭症谱系障碍（ASD）是一种病因不明的常见神经发育障碍。研究表明自闭症与新生儿黄疸之间存在联系。对2002年10月至2009年9月在军事卫生系统登记出生的儿童进行了一项1:3匹配的病例对照研究。使用诊断和程序代码来识别ASD和高胆红素血症。评估了高胆红素血症的两种定义：诊断为黄疸并接受光疗的住院治疗。该研究共纳入了2917名患有ASD的儿童和8751名匹配的对照。调整后，儿童ASD与诊断为黄疸的住院治疗之间仍存在关联（比值比=1.18；95%置信区间=1.06-1.31；P=0.001）以及与光疗治疗之间存在关联（比值比=1.33；95%置信区间=1.04-1.69；P=0.008）。患ASD的儿童在新生儿期更有可能因诊断为黄疸而住院，并且更有可能因该黄疸而需要治疗。
