兰氏锥虫微管蛋白基因的特征分析。

Characterization of tubulin genes in Trypanosoma rangeli.

作者信息

Esquenazi D, Morel C M, Traub-Cseko Y M

机构信息

Departamento de Bioquímica e Biologia Molecular, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

出版信息

Mol Biochem Parasitol. 1989 May 15;34(3):253-9. doi: 10.1016/0166-6851(89)90054-6.

DOI:10.1016/0166-6851(89)90054-6

PMID:2733730

Abstract

Tubulin genes in Trypanosoma rangeli, the only trypanosome besides T. cruzi to infect humans in America, are organized in homogeneous, alternate alpha and beta gene tandem repeats of 3.8 kb. The basic repeat was cloned, mapped and partially sequenced. In contrast to most other eukaryotes, where tubulin genes are scattered throughout the genome, trypanosomatids so far studied are characterized by tandem arrangements of these genes with the genus Trypanosoma displaying an alternating alpha- and beta-tubulin tandem repeat.

摘要

在美洲锥虫属（Trypanosoma）中，除克氏锥虫（T. cruzi）外，唯一能感染人类的锥虫——兰氏锥虫（Trypanosoma rangeli）的微管蛋白基因，以3.8 kb的均匀、交替的α和β基因串联重复形式排列。对基本重复序列进行了克隆、定位和部分测序。与大多数其他真核生物不同，在其他真核生物中微管蛋白基因分散在整个基因组中，而迄今为止所研究的锥虫的特征是这些基因呈串联排列，锥虫属显示出交替的α-和β-微管蛋白串联重复。