University of Pittsburgh School of Medicine, Division of Infectious Diseases, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224.
Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.DMIH2-0011-2015.
This review covers relevant clinical and laboratory information relating to Epstein-Barr virus (EBV) infections in immunocompromised hosts. It describes the epidemiology and clinical manifestations with a primary focus on disease in solid organ and stem cell transplant recipients. The review pays particular attention to diagnostic approaches, including serologic testing and imaging, with an expanded discussion on the role of measuring the EBV load in peripheral blood, identifying both strengths and limitations of this assay. Additional attention is paid to potential additional strategies of immunologic monitoring that may enhance the performance of EBV load monitoring.
本文综述了与免疫功能低下宿主中 Epstein-Barr 病毒 (EBV) 感染相关的临床和实验室信息。它描述了流行病学和临床表现，主要关注实体器官和干细胞移植受者的疾病。本文特别关注诊断方法，包括血清学检测和影像学检查，并扩展讨论了外周血 EBV 载量测量在诊断中的作用，阐明了该检测方法的优势和局限性。本文还关注了可能增强 EBV 载量监测性能的潜在免疫监测策略。
