Damm K, Thompson C C, Evans R M
Gene Expression Laboratory, Howard Hughes Medical Institute, La Jolla, California.
Nature. 1989 Jun 22;339(6226):593-7. doi: 10.1038/339593a0.
The thyroid-hormone receptor can, in the absence of its ligand, suppress activity of a responsive promoter. Addition of thyroid hormone, however, results in the stimulation of expression. The oncogenic derivative of the thyroid-hormone receptor, v-erbA, acts as a constitutive repressor and, when coexpressed with the receptor, blocks activation by thyroid hormone. Thus, v-erbA may be the first example of a dominant negative oncogene.
在没有配体的情况下，甲状腺激素受体可以抑制反应性启动子的活性。然而，添加甲状腺激素会导致表达的刺激。甲状腺激素受体的致癌衍生物v-erbA作为一种组成型阻遏物，当与受体共表达时，会阻断甲状腺激素的激活作用。因此，v-erbA可能是显性负癌基因的第一个例子。
