• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Does p49/STRAP, a SRF-binding protein (SRFBP1), modulate cardiac mitochondrial function in aging?p49/STRAP（一种血清反应因子结合蛋白（SRFBP1））是否会调节衰老过程中心脏线粒体的功能？
Exp Gerontol. 2016 Sep;82:150-9. doi: 10.1016/j.exger.2016.06.008. Epub 2016 Jun 20.
2
Overexpression of p49/STRAP alters cellular cytoskeletal structure and gross anatomy in mice.p49/STRAP的过表达改变了小鼠的细胞细胞骨架结构和大体解剖结构。
BMC Cell Biol. 2014 Sep 2;15:32. doi: 10.1186/1471-2121-15-32.
3
Identification of a subunit of NADH-dehydrogenase as a p49/STRAP-binding protein.鉴定NADH脱氢酶的一个亚基为p49/STRAP结合蛋白。
BMC Cell Biol. 2008 Jan 29;9:8. doi: 10.1186/1471-2121-9-8.
4
Identification of a novel serum response factor cofactor in cardiac gene regulation.鉴定一种参与心脏基因调控的新型血清反应因子辅因子。
J Biol Chem. 2004 Dec 31;279(53):55626-32. doi: 10.1074/jbc.M405945200. Epub 2004 Oct 18.
5
p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts.p300在维持出生后心脏的心肌线粒体功能和细胞存活方面发挥着关键作用。
Circ Res. 2009 Oct 9;105(8):746-54. doi: 10.1161/CIRCRESAHA.109.206037. Epub 2009 Sep 3.
6
Mitochondrial biogenesis and PGC-1α deacetylation by chronic treadmill exercise: differential response in cardiac and skeletal muscle.慢性跑步机运动对线粒体生物发生和 PGC-1α 去乙酰化的影响：在心脏和骨骼肌中的不同反应。
Basic Res Cardiol. 2011 Nov;106(6):1221-34. doi: 10.1007/s00395-011-0213-9. Epub 2011 Aug 28.
7
Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1α signaling contributing to increased vulnerability in diabetic heart.由于脂联素-AMPK-PGC-1α信号通路功能障碍导致的线粒体生物发生受损导致糖尿病心脏易损性增加。
Basic Res Cardiol. 2013 May;108(3):329. doi: 10.1007/s00395-013-0329-1. Epub 2013 Mar 5.
8
Metformin improves cardiac function in mice with heart failure after myocardial infarction by regulating mitochondrial energy metabolism.二甲双胍通过调节线粒体能量代谢改善心肌梗死后心力衰竭小鼠的心脏功能。
Biochem Biophys Res Commun. 2017 Apr 29;486(2):329-335. doi: 10.1016/j.bbrc.2017.03.036. Epub 2017 Mar 14.
9
p49/STRAP, a Serum Response Factor Binding Protein (SRFBP1), Is Involved in the Redistribution of Cytoskeletal F-Actin Proteins during Glucose Deprivation.p49/STRAP，一种血清反应因子结合蛋白（SRFBP1），在葡萄糖剥夺期间参与细胞骨架F-肌动蛋白蛋白的重新分布。
J Nutr Health Aging. 2017;21(10):1142-1150. doi: 10.1007/s12603-017-0925-0.
10
Acetylation of PGC1α by Histone Deacetylase 1 Downregulation Is Implicated in Radiation-Induced Senescence of Brain Endothelial Cells.组蛋白去乙酰化酶 1 的下调导致 PGC1α 的乙酰化，这与脑内皮细胞辐射诱导的衰老有关。
J Gerontol A Biol Sci Med Sci. 2019 May 16;74(6):787-793. doi: 10.1093/gerona/gly167.

引用本文的文献

1
Alternative Splicing of Serum Response Factor Reveals Isoform-Specific Remodeling in Cardiac Diseases.血清反应因子的可变剪接揭示了心脏疾病中特定亚型的重塑。
Genes (Basel). 2025 Aug 11;16(8):947. doi: 10.3390/genes16080947.
2
The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function.沉默调节蛋白1亚型在调节线粒体功能中的作用
Curr Issues Mol Biol. 2024 Aug 14;46(8):8835-8851. doi: 10.3390/cimb46080522.
3
Metabolic Changes in Cardiac Aging.心脏衰老过程中的代谢变化。
Rev Cardiovasc Med. 2023 Mar 6;24(3):82. doi: 10.31083/j.rcm2403082. eCollection 2023 Mar.
4
Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function.Rho/MRTF/SRF转录途径抑制剂调节线粒体功能。
Cells. 2024 Feb 24;13(5):392. doi: 10.3390/cells13050392.
5
-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress.LPS 通过氧化应激诱导神经炎症介导的线粒体功能障碍。
Int J Mol Sci. 2023 Jan 4;24(2):950. doi: 10.3390/ijms24020950.
6
Rho/SRF Inhibitor Modulates Mitochondrial Functions.Rho/SRF 抑制剂调节线粒体功能。
Int J Mol Sci. 2022 Sep 29;23(19):11536. doi: 10.3390/ijms231911536.
7
SRF: a seriously responsible factor in cardiac development and disease.SRF：心脏发育和疾病中的一个重要因素。
J Biomed Sci. 2022 Jun 9;29(1):38. doi: 10.1186/s12929-022-00820-3.
8
Targeting NAD+: is it a common strategy to delay heart aging?靶向NAD⁺：这是延缓心脏衰老的常见策略吗？
Cell Death Discov. 2022 Apr 26;8(1):230. doi: 10.1038/s41420-022-01031-3.
9
The Role of Histone Protein Acetylation in Regulating Endothelial Function.组蛋白乙酰化在调节内皮功能中的作用
Front Cell Dev Biol. 2021 Apr 29;9:672447. doi: 10.3389/fcell.2021.672447. eCollection 2021.

本文引用的文献

1
The Mitochondrial Basis of Aging.衰老的线粒体基础
Mol Cell. 2016 Mar 3;61(5):654-666. doi: 10.1016/j.molcel.2016.01.028.
2
The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging.组蛋白去乙酰化酶抑制剂丁酸可改善衰老过程中的新陈代谢并减少肌肉萎缩。
Aging Cell. 2015 Dec;14(6):957-70. doi: 10.1111/acel.12387. Epub 2015 Aug 20.
3
Elevated oxygen consumption rate in response to acute low-glucose stress: Metformin restores rate to normal level.急性低血糖应激下氧消耗率升高：二甲双胍将该率恢复至正常水平。
Exp Gerontol. 2015 Oct;70:157-62. doi: 10.1016/j.exger.2015.08.002. Epub 2015 Aug 7.
4
Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts.线粒体分裂和融合因子相互协调小鼠心脏和培养的成纤维细胞中的线粒体自噬清除。
Cell Metab. 2015 Feb 3;21(2):273-286. doi: 10.1016/j.cmet.2014.12.011. Epub 2015 Jan 15.
5
Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission.F-肌动蛋白在线粒体外膜上的瞬时组装有助于线粒体分裂。
J Cell Biol. 2015 Jan 5;208(1):109-23. doi: 10.1083/jcb.201404050. Epub 2014 Dec 29.
6
Overexpression of p49/STRAP alters cellular cytoskeletal structure and gross anatomy in mice.p49/STRAP的过表达改变了小鼠的细胞细胞骨架结构和大体解剖结构。
BMC Cell Biol. 2014 Sep 2;15:32. doi: 10.1186/1471-2121-15-32.
7
Mitochondrial fusion is frequent in skeletal muscle and supports excitation-contraction coupling.线粒体融合在骨骼肌中很频繁，支持兴奋-收缩耦联。
J Cell Biol. 2014 Apr 28;205(2):179-95. doi: 10.1083/jcb.201312066. Epub 2014 Apr 21.
8
Integrating mitochondrial organization and dynamics with cellular architecture.将线粒体组织和动态与细胞结构整合起来。
Curr Opin Cell Biol. 2014 Feb;26:34-40. doi: 10.1016/j.ceb.2013.09.002. Epub 2013 Oct 8.
9
A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth.过氧化物酶体增殖物激活受体 γ 共激活因子 1 在出生后心脏生长过程中线粒体动力学控制中的作用。
Circ Res. 2014 Feb 14;114(4):626-36. doi: 10.1161/CIRCRESAHA.114.302562. Epub 2013 Dec 23.
10
Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity.由线粒体融合蛋白调控的线粒体动态控制 Agrp 神经元活性和饮食诱导的肥胖。
Cell. 2013 Sep 26;155(1):188-99. doi: 10.1016/j.cell.2013.09.004.

p49/STRAP（一种血清反应因子结合蛋白（SRFBP1））是否会调节衰老过程中心脏线粒体的功能？

Does p49/STRAP, a SRF-binding protein (SRFBP1), modulate cardiac mitochondrial function in aging?

作者信息

Zhang Xiaomin, Williams Emmanuel D, Azhar Gohar, Rogers Steven C, Wei Jeanne Y

机构信息

Donald W. Reynolds Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.

Donald W. Reynolds Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.

出版信息

Exp Gerontol. 2016 Sep;82:150-9. doi: 10.1016/j.exger.2016.06.008. Epub 2016 Jun 20.

DOI:10.1016/j.exger.2016.06.008
PMID:27337995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4969173/
Abstract

p49/STRAP (SRFBP1) is a transcriptional regulator that has been implicated in cardiac aging. p49/STRAP has a SRF binding domain and a BUD22 domain (which modulates cellular growth rate and cell size). We have observed that p49/STRAP alters the intracellular NAD/NADH ratio and induces protein deacetylation. Here we report that p49/STRAP overexpression caused the deacetylation of histone H4 on lysine 16 (H4K16) and suppressed the expression of PGC-1α as well as mitofusin-1 and mitofusin-2 at both the mRNA and protein levels. P49/STRAP also reduced mitochondrial size, mitochondrial membrane potential and the mitochondrial oxygen consumption rate. We noted that P49/STRAP expression was increased in the old versus young adult mouse hearts and also increased with advancing population doubling levels in cultured human umbilical vein endothelial cells (HUVECs). It is therefore very plausible that increased expression of p49/STRAP in late life may alter the status of histone acetylation and impact mitochondrial dynamics and thereby reduce mitochondrial function and cardiac performance during mammalian senescence.

摘要

p49/STRAP（SRFBP1）是一种转录调节因子，与心脏衰老有关。p49/STRAP具有一个SRF结合结构域和一个BUD22结构域（可调节细胞生长速率和细胞大小）。我们观察到p49/STRAP会改变细胞内NAD/NADH比值并诱导蛋白质去乙酰化。在此我们报告，p49/STRAP的过表达导致组蛋白H4赖氨酸16位点（H4K16）去乙酰化，并在mRNA和蛋白质水平上抑制PGC-1α以及线粒体融合蛋白1和线粒体融合蛋白2的表达。p49/STRAP还会减小线粒体大小、降低线粒体膜电位以及线粒体氧消耗率。我们注意到，与年轻成年小鼠心脏相比，老年小鼠心脏中p49/STRAP的表达增加，并且在培养的人脐静脉内皮细胞（HUVECs）中，随着群体倍增水平的提高其表达也增加。因此，很有可能在生命后期p49/STRAP表达的增加会改变组蛋白乙酰化状态，影响线粒体动力学，从而在哺乳动物衰老过程中降低线粒体功能和心脏性能。