Al-Regaiey K A
Department of Physiology, Aging Research Chair, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Eur Rev Med Pharmacol Sci. 2016 Jun;20(11):2468-73.
Calorie restriction (CR) without malnutrition slows aging and increase average and maximal lifespan in model organisms and rodents. In human and non-human primates, CR has beneficial effects on human longevity and reduces the incidence of age-related diseases such as obesity, diabetes mellitus hypertension, cardiovascular disease and cancer. CR exerts its anti-aging effects through different mechanisms including small noncoding RNA molecules (sncRNAs), the composition of diet and IGF-1 signaling. The aim of this review was to discuss recent developments to understand the consequences and mechanisms of CR on longevity.
在不造成营养不良的情况下进行热量限制（CR），可延缓衰老，并延长模式生物和啮齿动物的平均寿命和最大寿命。在人类和非人类灵长类动物中，热量限制对人类长寿具有有益影响，并可降低肥胖、糖尿病、高血压、心血管疾病和癌症等与年龄相关疾病的发病率。热量限制通过不同机制发挥其抗衰老作用，包括小分子非编码RNA分子（sncRNAs）、饮食组成和胰岛素样生长因子-1（IGF-1）信号传导。本综述的目的是讨论近期的研究进展，以了解热量限制对长寿的影响及其机制。
