UMR CNRS/MNHN 7179, Mécanismes Adaptatifs et Evolution, 1 Avenue du Petit Château, 91800 Brunoy, France.
UMR CNRS/MNHN 7179, Mécanismes Adaptatifs et Evolution, 1 Avenue du Petit Château, 91800 Brunoy, France.
Prog Neuropsychopharmacol Biol Psychiatry. 2019 Dec 20;95:109702. doi: 10.1016/j.pnpbp.2019.109702. Epub 2019 Jul 17.
The health benefits of chronic caloric restriction (CR) resulting in lifespan extension are well established in many species and has been recently demonstrated also in non-human primates, but its effects in humans remain to be proven on a long-term basis. CR might be a very efficient anti-aging strategy but its definition and limits must be well understood before envisaging to apply it to human. In this review, we first report and compare the recently issued CR studies in non-human primates and humans and then try to understand what an optimal caloric intake is. In a last part, we will discuss the pertinence of using CR as an anti-aging strategy with respect to the risks of frailty and obesity.
慢性热量限制（CR）对延长寿命的健康益处已在许多物种中得到充分证实，最近也在非人类灵长类动物中得到证实，但在长期基础上其对人类的影响仍有待证明。CR 可能是一种非常有效的抗衰老策略，但在考虑将其应用于人类之前，必须充分了解其定义和限制。在这篇综述中，我们首先报告和比较了最近发表的非人类灵长类动物和人类的 CR 研究，然后试图了解最佳热量摄入是多少。在最后一部分，我们将讨论使用 CR 作为抗衰老策略的相关性，以及脆弱和肥胖的风险。
