Zhang Fuyong, Liu Chunli, Qian Linlin, Hou Haifeng, Guo Zhengyi
, Taian City Central Hospital, Taian, Shandong, China (mainland).
, Taishan Medical University, Taian, Shandong, China (mainland).
Med Sci Monit. 2016 Jun 24;22:2167-74. doi: 10.12659/msm.896471.
BACKGROUND This investigation aimed to evaluate changes in apparent diffusion coefficient (ADC) and fractional anisotropy (FA) of white matter injury (WMI) in preterm neonates with hypoxic-ischemic encephalopathy (HIE) using diffusion tension imaging (DTI). MATERIAL AND METHODS Thirty-eight neonates less than 37 weeks of gestation with leukoencephalopathy (as observation group) and 38 full-term infants with no leukoencephalopathy (as control group) were selected from the Neonatal Care Center in Taian Central Hospital from January 2012 to December 2013. A DTI scan was obtained within 1 week after birth. RESULTS In the observation group, on both sides the ADC values in regions of interest (ROI) of white matter, lesions were greater and FA values were lower than in the control group. ADC and FA values in genu and splenum of corpus callosum were statistically different between the mild and severe injury groups (p<0.05). CONCLUSIONS This study demonstrates that DTI provides sensitive detection and early diagnosis of WMI in brains of premature infants with HIE.
背景 本研究旨在利用扩散张量成像（DTI）评估缺氧缺血性脑病（HIE）早产儿脑白质损伤（WMI）的表观扩散系数（ADC）和各向异性分数（FA）的变化。
材料与方法 选取2012年1月至2013年12月泰安市中心医院新生儿监护中心的38例孕周小于37周的白质脑病新生儿（作为观察组）和38例无白质脑病的足月儿（作为对照组）。出生后1周内进行DTI扫描。
结果 观察组双侧脑白质感兴趣区（ROI）的ADC值高于对照组，FA值低于对照组。胼胝体膝部和压部的ADC和FA值在轻度和重度损伤组之间有统计学差异（p<0.05）。
结论 本研究表明，DTI能敏感地检测和早期诊断HIE早产儿脑内的WMI。
