Duxbury Zane, Ma Yan, Furzer Oliver J, Huh Sung Un, Cevik Volkan, Jones Jonathan D G, Sarris Panagiotis F
The Sainsbury Laboratory, Norwich Research Park, Norwich, UK.
Division of Plant and Microbial Sciences, School of Biosciences, University of Exeter, Exeter, UK.
Bioessays. 2016 Aug;38(8):769-81. doi: 10.1002/bies.201600046. Epub 2016 Jun 24.
Intracellular NLR (Nucleotide-binding domain and Leucine-rich Repeat-containing) receptors are sensitive monitors that detect pathogen invasion of both plant and animal cells. NLRs confer recognition of diverse molecules associated with pathogen invasion. NLRs must exhibit strict intramolecular controls to avoid harmful ectopic activation in the absence of pathogens. Recent discoveries have elucidated the assembly and structure of oligomeric NLR signalling complexes in animals, and provided insights into how these complexes act as scaffolds for signal transduction. In plants, recent advances have provided novel insights into signalling-competent NLRs, and into the myriad strategies that diverse plant NLRs use to recognise pathogens. Here, we review recent insights into the NLR biology of both animals and plants. By assessing commonalities and differences between kingdoms, we are able to develop a more complete understanding of NLR function.
细胞内NLR（核苷酸结合结构域和富含亮氨酸重复序列）受体是检测植物和动物细胞病原体入侵的敏感监测器。NLR能够识别与病原体入侵相关的多种分子。NLR必须表现出严格的分子内控制，以避免在没有病原体的情况下发生有害的异位激活。最近的发现阐明了动物中寡聚NLR信号复合物的组装和结构，并为这些复合物如何作为信号转导支架提供了见解。在植物中，最近的进展为具有信号传导能力的NLR以及各种植物NLR识别病原体的众多策略提供了新的见解。在这里，我们综述了对动物和植物NLR生物学的最新见解。通过评估不同生物界之间的共性和差异，我们能够更全面地了解NLR的功能。
