National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.
Mol Plant Pathol. 2022 Jun;23(6):772-780. doi: 10.1111/mpp.13195. Epub 2022 Mar 30.
Plant intracellular immune receptors known as NLR (nucleotide-binding leucine-rich repeat) proteins confer immunity and cause cell death. Plant NLR proteins that directly or indirectly recognize pathogen effector proteins to initiate immune signalling are regarded as sensor NLRs. Some NLR protein families function downstream of sensor NLRs to transduce immune signalling and are known as helper NLRs. Recent breakthrough studies on plant NLR protein structures and biochemical functions greatly advanced our understanding of NLR biology. Comprehensive and detailed knowledge on NLR biology requires future efforts to solve more NLR protein structures and investigate the signalling events between sensor and helper NLRs, and downstream of helper NLRs.
植物细胞内的免疫受体被称为 NLR（核苷酸结合富含亮氨酸重复）蛋白，它们赋予植物免疫和引起细胞死亡的能力。植物 NLR 蛋白直接或间接识别病原体效应蛋白以启动免疫信号，被认为是感应 NLR 蛋白。一些 NLR 蛋白家族在感应 NLR 蛋白下游发挥作用，传递免疫信号，被称为辅助 NLR 蛋白。近期关于植物 NLR 蛋白结构和生化功能的突破性研究极大地推动了我们对 NLR 生物学的理解。全面和详细的 NLR 生物学知识需要未来的努力来解决更多的 NLR 蛋白结构，并研究感应 NLR 蛋白和辅助 NLR 蛋白之间，以及辅助 NLR 蛋白下游的信号事件。
