氧化应激和炎症介质在良性阵发性位置性眩晕中的作用
The Role of Oxidative Stress and Inflammatory Mediators in Benign Paroxysmal Positional Vertigo.
作者信息
Güçlütürk Mehmet Taylan, Ünal Zeynep Nil, İsmi Onur, Çimen Mehmet Burak Yavuz, Ünal Murat
机构信息
Department of Otorhinolaryngology, Mersin University School of Medicine, Mersin, Turkey.
出版信息
J Int Adv Otol. 2016 Apr;12(1):101-5. doi: 10.5152/iao.2015.1412.
OBJECTIVE
Benign paroxysmal positional vertigo (BPPV) is the most common peripheral cause of vertigo. It can be defined as transient vertigo induced by rapid changes in head position associated with a characteristic paroxysmal positional nystagmus. The aim of this study was to search for the possible role of oxidative stress and inflammatory mediators in the pathogenesis of BPPV.
MATERIALS AND METHODS
Total antioxidant status as well as paraoxonase, tumor necrosis factor alpha, interleukin (IL) 6, and IL-1β levels were evaluated in peripheral venous serum samples of 30 BPPV and 30 control patients.
RESULTS
Total antioxidant status levels were lower in the BPPV group than in the control group (p=0.008). After Epley's repositioning maneuver in the vertigo group, there was a statistically significant decline in IL-1β levels at the first and third month visits (p=0.014 for first month and p=0.013 for third month).
CONCLUSION
Our findings suggested that IL-1β and oxidative stress contributed to the pathogenesis of BPPV.
目的
良性阵发性位置性眩晕（BPPV）是眩晕最常见的外周性病因。它可被定义为由头部位置快速变化诱发的短暂性眩晕，并伴有特征性的阵发性位置性眼球震颤。本研究的目的是探寻氧化应激和炎症介质在BPPV发病机制中的可能作用。
材料与方法
对30例BPPV患者和30例对照患者的外周静脉血清样本进行总抗氧化状态以及对氧磷酶、肿瘤坏死因子α、白细胞介素（IL）-6和IL-1β水平的评估。
结果
BPPV组的总抗氧化状态水平低于对照组（p = 0.008）。在眩晕组进行Epley复位手法后，在首次和第三个月随访时IL-1β水平有统计学意义的下降（第一个月p = 0.014，第三个月p = 0.013）。
结论
我们的研究结果提示IL-1β和氧化应激促成了BPPV的发病机制。
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