患有眩晕的新冠病毒肺炎患者的白细胞介素-6血清水平
IL-6 Serum Levels in COVID-19 Patients With Vertigo.
作者信息
Kitsos Dimitrios, Tzartos John, Korres George, Giannopapas Vasileios, Riga Maria, Stergiou Christos, Tsoga Anthi, Grigoropoulos Christos, Paraskevas Georgios, Zompola Christina, Nikolopoulos Thomas, Giannopoulos Sotirios
机构信息
Department of Neurology, Attikon University Hospital, Athens, GRC.
Department of Otolaryngology, National and Kapodistrian University of Athens School of Medicine, Athens, GRC.
出版信息
Cureus. 2023 Feb 16;15(2):e35042. doi: 10.7759/cureus.35042. eCollection 2023 Feb.
Introduction Dizziness and vertigo represent well-established symptoms of COVID-19. An overexpression of cytokines, a condition often described with the term "cytokine storm" or "hypercytokinemia", is a key characteristic of SARS-Cov-2 infection and plays a pivotal role in disease progression and prognosis. Among them, IL-6 is of major importance. Purpose The purpose of this study is to investigate any probable IL-6 serum titer difference in COVID-19 patients with vertigo (V+) or without vertigo (V-) admitted to the COVID-19 internal medicine departments of Attikon University Hospital, Athens, Greece, within 12 months. Methods The sample consisted of 52 COVID-19 patients who were diagnosed between January 1, 2020, and December 31, 2020. Of those, 31 reported vertigos during their admission (V+), while the remaining 21 COVID-19 patients did not complain of such symptoms (V-). Results Higher IL-6 serum levels post-COVID-19 infections lead to higher incidence rates of vertigo symptoms (p<.005), regardless of gender and age (p.005).
引言 头晕和眩晕是新冠肺炎公认的症状。细胞因子的过度表达，通常用“细胞因子风暴”或“高细胞因子血症”来描述，是新冠病毒感染的一个关键特征，在疾病进展和预后中起关键作用。其中，白细胞介素-6（IL-6）尤为重要。
目的 本研究的目的是调查在希腊雅典阿提卡大学医院内科收治的新冠肺炎患者中，在12个月内有眩晕（V+）或无眩晕（V-）的患者之间，IL-6血清滴度是否存在差异。
方法 样本包括2020年1月1日至2020年12月31日期间确诊的52例新冠肺炎患者。其中，31例在入院期间报告有眩晕（V+），而其余21例新冠肺炎患者没有此类症状（V-）。
结果 新冠病毒感染后较高的IL-6血清水平导致眩晕症状的发生率更高（p<0.005），无论性别和年龄如何（p.005）。
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