Materials Research Laboratory, University of California , Santa Barbara, California 93106, United States.
Institute of Particle Technology, Friedrich-Alexander University Erlangen-Nürnberg , Haberstrasse 9a, 91058 Erlangen, Germany.
ACS Appl Mater Interfaces. 2016 Jul 6;8(26):16914-21. doi: 10.1021/acsami.6b03356. Epub 2016 Jun 24.
Well-defined microgel particles were prepared by combining coacervate-driven cross-linking of ionic triblock copolymers with the ability to control particle size and encapsulate functional cargos inherent in microfluidic devices. In this approach, the efficient assembly of PEO-based triblock copolymers with oppositely charged end-blocks allows for bioinspired cross-linking under mild conditions in dispersed aqueous droplets. This strategy enables the integration of charged cargos into the coacervate domains (e.g., the loading of anionic model compounds through electrostatic association with cationic end-blocks). Distinct release profiles can be realized by systematically varying the chemical nature of the payload and the microgel dimensions. This mild and noncovalent assembly method represents a promising new approach to tunable microgels as scaffolds for colloidal biomaterials in therapeutics and regenerative medicine.
通过将具有控制粒径和包封功能载物能力的凝聚相驱动的离子两亲嵌段共聚物的交联与微流控设备相结合，制备了结构明确的微凝胶颗粒。在这种方法中，具有相反电荷端基的基于 PEO 的两亲嵌段共聚物的有效组装允许在分散的水相液滴中在温和条件下进行仿生交联。该策略允许将带电荷的载物（例如，通过与阳离子端基静电结合来加载阴离子模型化合物）整合到凝聚相域中。通过系统地改变有效载荷的化学性质和微凝胶的尺寸，可以实现独特的释放曲线。这种温和的非共价组装方法代表了一种有前途的新方法，可将可调谐微凝胶作为胶体生物材料在治疗和再生医学中的支架。
