Langille G, Yang H, Zeisler S K, Hoehr C, Storr T, Andreoiu C, Schaffer P
Department of Chemistry, Simon Fraser University, Burnaby, Canada.
Life Sciences Division, TRIUMF, Vancouver, Canada.
Appl Radiat Isot. 2016 Sep;115:81-86. doi: 10.1016/j.apradiso.2016.06.005. Epub 2016 Jun 7.
This work demonstrates the labelling of a novel class of iridium lumophore with radioiridium, as proof-of-feasibility for producing and using the medically useful isotope iridium-192. Natural osmium was electroplated onto silver target backings in basic media and irradiated for up to two hours with ≤20μA of 12.8MeV protons. A range of iridium isotopes were generated, characterized and quantified using γ-spectroscopy methods. The target material was removed from the backings via oxidative dissolution with hydrogen peroxide, and the iridium radioisotopes isolated using an anion exchange resin. Both no-carrier-added as well as carrier-added formulations were then used in subsequent cyclometalation reactions.
这项工作展示了用放射性铱标记一类新型铱发光体，以此作为生产和使用医学上有用的同位素铱 - 192的可行性证明。在碱性介质中将天然锇电镀到银靶衬底上，并用≤20μA的12.8MeV质子辐照长达两小时。使用γ能谱法生成、表征并定量了一系列铱同位素。通过用过氧化氢进行氧化溶解将靶材料从衬底上去除，并使用阴离子交换树脂分离铱放射性同位素。然后将无载体添加以及有载体添加的制剂用于随后的环金属化反应。
