Cheng C, Treves S, Samuel A, Davis M A
J Nucl Med. 1980 Dec;21(12):1169-76.
A new osmium-191 leads to iridium-191m generator suitable for first-pass radionuclide angiocardiography has been developed. This generator system allows repeated elutions of 4.96-sec iridium-191m from its 15.4-day Os- 191 parent. The Os-191 is loaded on an anion-exchange column (AGMP-1) and Ir- 191m eluted with 0.9% NaCl at pH 1. Each elution (0.6 to 1 ml) of the generator yields about 7 to 10% Ir-191m and gives 0.003-0.008% of Os-191 breakthrough. Toxicity studies of the generator eluate carried out in animals support the safety of using iridium-191m in humans. The long shelf-life of the generator (approximately equal to 2 wk) will allow medical centers to use Ir- 191m for routine clinical diagnosis. Iridium-191m obtained by this method should find additional useful applications in nuclear medicine.
一种适用于首次通过放射性核素血管造影术的新型锇 - 191 到铱 - 191m 发生器已被研发出来。该发生器系统允许从其 15.4 天的锇 - 191 母体中反复洗脱半衰期为 4.96 秒的铱 - 191m。锇 - 191 被装载在阴离子交换柱（AGMP - 1）上，铱 - 191m 用 pH 值为 1 的 0.9%氯化钠溶液洗脱。发生器的每次洗脱（0.6 至 1 毫升）产生约 7%至 10%的铱 - 191m，并且锇 - 191 的突破率为 0.003% - 0.008%。在动物身上进行的发生器洗脱液毒性研究支持了在人体中使用铱 - 191m 的安全性。发生器的长保质期（约等于 2 周）将使医疗中心能够将铱 - 191m 用于常规临床诊断。通过这种方法获得的铱 - 191m 在核医学中应会有更多有用的应用。
