Gimeno Forner L, Bolant Hernández B, Calvo Bermúdez M A, Ariño Matíez J, Palomar Pérez E F, Amorós Escolar J C, Lloris Carsí J M, Narbona B
Rev Esp Enferm Apar Dig. 1989 Mar;75(3):225-30.
A study was made of the effect of rice chaff oil (ASA) on gastroduodenal ulcer (UGD) induced by different techniques: cysteaminium chloride, indomethacin, artificial gastric juices and stress (acidity, histamine, pepsin and volume of gastric juice were evaluated). For each technique the same protocol was followed: four days before the experiment 20 Wistar rats (180-220 g) were divided into a control group (0.2 ml/day of saline solution per os) and a treated group (0.2 ml/day of oral rice chaff oil). After quantitation of the ulcers and statistical analysis of the data, the ulcer index was found to be smaller in the treated group than in controls, both for stress ulcers (p less than 0.01) and for those induced by indomethacin (p less than 0.001) and artificial gastric juice (p less than 0.001). As for the cysteaminium chloride technique, an evaluation was made of the ulcer per se and the inflammatory halo; in both cases there were significant differences (p less than 0.05 and p less than 0.01 respectively) between the treated group and controls. No significant differences were found on comparing the values off histamine, pepsin and the volume of gastric juices, but there were differences in hydrogen ion concentration (p less than 0.05). An analysis is made of the physiologic aspects studied in each technique, emphasizing the possible implication of prostaglandins (PG) and alpha-tocopherol after treatment with rice chaff oil.
研究了米糠油（ASA）对不同方法诱导的胃十二指肠溃疡（UGD）的影响：氯化半胱胺、吲哚美辛、人工胃液和应激（评估胃酸、组胺、胃蛋白酶和胃液量）。对于每种方法，均遵循相同的方案：实验前4天，将20只Wistar大鼠（180 - 220克）分为对照组（口服0.2毫升/天的生理盐水）和治疗组（口服0.2毫升/天的米糠油）。在对溃疡进行定量并对数据进行统计分析后，发现治疗组的溃疡指数在应激性溃疡（p < 0.01）、吲哚美辛诱导的溃疡（p < 0.001）和人工胃液诱导的溃疡（p < 0.001）方面均低于对照组。至于氯化半胱胺方法，对溃疡本身和炎性晕进行了评估；在这两种情况下，治疗组与对照组之间均存在显著差异（分别为p < 0.05和p < 0.01）。在比较组胺、胃蛋白酶和胃液量的值时未发现显著差异，但在氢离子浓度方面存在差异（p < 0.05）。对每种方法中研究的生理方面进行了分析，强调了米糠油治疗后前列腺素（PG）和α - 生育酚的可能作用。
