新生儿缺氧缺血性脑病的低温治疗：美国国立儿童健康与人类发展研究所新生儿研究网络对该领域的贡献。
Hypothermia for neonatal hypoxic-ischemic encephalopathy: NICHD Neonatal Research Network contribution to the field.
作者信息
Shankaran Seetha, Natarajan Girija, Chalak Lina, Pappas Athina, McDonald Scott A, Laptook Abbot R
机构信息
Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, MI 48201.
Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, MI 48201.
出版信息
Semin Perinatol. 2016 Oct;40(6):385-390. doi: 10.1053/j.semperi.2016.05.009. Epub 2016 Jun 23.
Abstract
In this article, we summarize the NICHD Neonatal Research Network (NRN) trial of whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy in relation to other randomized controlled trials (RCTs) of hypothermia neuroprotection. We describe the NRN secondary studies that have been published in the past 10 years evaluating clinical, genetic, biochemical, and imaging biomarkers of outcome.
摘要
在本文中，我们总结了美国国立儿童健康与人类发展研究所新生儿研究网络（NRN）针对缺氧缺血性脑病新生儿进行的全身低温治疗试验，并将其与其他低温神经保护随机对照试验（RCT）进行了比较。我们描述了过去10年发表的NRN二次研究，这些研究评估了临床、基因、生化和影像学方面的预后生物标志物。
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