University of Western Ontario, London Health Sciences Centre, Department of Medicine, Division of Gastroenterology, Canada.
Ann Hepatol. 2012 May-Jun;11(3):294-300.
Elevated serum ferritin, or hyperferritinemia, is a common finding on routine bloodwork and often prompts referral for further evaluation. In the following review, we outline the various causes of hyperferritinemia and point out that, in the majority of cases, this does not represent true iron overload. Despite much research interest in this area, the precise mechanism of hyperferritinemia and its impact on disease severity in various clinical conditions continues to be debated. While some research suggests that iron reduction in cases of hyperferritinemia is of benefit, the decision to treat such patients should be individualized, and may be influenced by the presence of other features of iron overload.
血清铁蛋白升高，或称为血铁蛋白过多，是常规血液检查中的常见发现，常提示进一步评估。在以下综述中，我们概述了血铁蛋白过多的各种原因，并指出，在大多数情况下，这并不代表真正的铁过载。尽管人们对这一领域非常感兴趣，但血铁蛋白过多的确切机制及其对各种临床情况下疾病严重程度的影响仍存在争议。虽然一些研究表明，在血铁蛋白过多的情况下减少铁的摄入有益，但治疗这些患者的决定应该是个体化的，并且可能受到其他铁过载特征的影响。
