Tekieh Tahereh, Sasanpour Pezhman, Rafii-Tabar Hashem
Computational Nano-Bioelectromagnetics Research Group, School of Nano-Science, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran.
Department of Medical Physics & Biomedical Engineering, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Computational Nano-Bioelectromagnetics Research Group, School of Nano-Science, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran.
Brain Res. 2016 Sep 1;1646:560-569. doi: 10.1016/j.brainres.2016.06.034. Epub 2016 Jun 23.
A three-dimensional Brownian Dynamics (BD) in combination with electrostatic calculations is employed to specifically study the effects of radiation of high frequency electromagnetic fields on the conduction and concentration profile of calcium ions inside the voltage-gated calcium channels. The electrostatic calculations are performed using COMSOL Multiphysics by considering dielectric interfaces effectively. The simulations are performed for different frequencies and intensities. The simulation results show the variations of conductance, average number of ions and the concentration profiles of ions inside the channels in response to high frequency radiation. The ionic current inside the channel increases in response to high frequency electromagnetic field radiation, and the concentration profiles show that the residency of ions in the channel decreases accordingly.
结合静电计算的三维布朗动力学（BD）被用于专门研究高频电磁场辐射对电压门控钙通道内钙离子传导和浓度分布的影响。通过有效考虑介电界面，使用COMSOL Multiphysics进行静电计算。针对不同频率和强度进行模拟。模拟结果显示了响应高频辐射时通道内的电导、离子平均数量和离子浓度分布的变化。通道内的离子电流响应高频电磁场辐射而增加，并且浓度分布表明通道内离子的驻留时间相应减少。
