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物理刺激对间充质干细胞软骨分化中钙通道的作用。

The Role of Physical Stimuli on Calcium Channels in Chondrogenic Differentiation of Mesenchymal Stem Cells.

机构信息

Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, LT-08406 Vilnius, Lithuania.

Department of Veterinary Pre-Clinical Sciences, School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7AL, UK.

出版信息

Int J Mol Sci. 2018 Oct 1;19(10):2998. doi: 10.3390/ijms19102998.

DOI:10.3390/ijms19102998
PMID:30275359
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6212952/
Abstract

Human mesenchymal stem cells (hMSC) are becoming increasingly popular in tissue engineering. They are the most frequently used stem cell source for clinical applications due to their high potential to differentiate into several lineages. Cartilage is known for its low capacity for self-maintenance and currently there are no efficient methods to improve cartilage repair. Chondrogenic differentiation of hMSC isolated from different tissues is widely employed due to a high clinical demand for the improvement of cartilage regeneration. Calcium channels that are regulated by physical stimuli seem to play a pivotal role in chondrogenic differentiation of MSCs. These channels increase intracellular calcium concentration, which leads to the initiation of the relevant cellular processes that are required for differentiation. This review will focus on the impact of different physical stimuli, including electrical, electromagnetic/magnetic and mechanical on various calcium channels and calcium signaling mechanisms during chondrogenic differentiation of hMSC.

摘要

人骨髓间充质干细胞（hMSC）在组织工程中越来越受欢迎。由于其向多个谱系分化的巨大潜力，它们是临床应用中最常使用的干细胞来源。软骨的自我维持能力较低，目前尚无有效的方法来改善软骨修复。由于临床上对改善软骨再生的需求很高，因此广泛采用分离自不同组织的 hMSC 的软骨分化。受物理刺激调节的钙通道似乎在 MSC 的软骨分化中起着关键作用。这些通道增加细胞内钙浓度，从而启动分化所需的相关细胞过程。本综述将重点介绍不同物理刺激（包括电、电磁/磁场和机械刺激）对 hMSC 软骨分化过程中各种钙通道和钙信号机制的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84af/6212952/e069a323d6f7/ijms-19-02998-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84af/6212952/5a817dbc9252/ijms-19-02998-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84af/6212952/e069a323d6f7/ijms-19-02998-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84af/6212952/5a817dbc9252/ijms-19-02998-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84af/6212952/e069a323d6f7/ijms-19-02998-g002.jpg

相似文献

[1]
The Role of Physical Stimuli on Calcium Channels in Chondrogenic Differentiation of Mesenchymal Stem Cells.

Int J Mol Sci. 2018-10-1

[2]
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[3]
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[4]
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[6]
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[7]
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[8]
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[9]
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[10]
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[5]
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[6]
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[7]
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[9]
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本文引用的文献

[1]
The chondrocyte channelome: A narrative review.

Joint Bone Spine. 2018-2-13

[2]
Enhancement of mesenchymal stem cell chondrogenesis with short-term low intensity pulsed electromagnetic fields.

Sci Rep. 2017-8-25

[3]
Control by Low Levels of Calcium of Mammalian Cell Membrane Electropermeabilization.

J Membr Biol. 2018-4

[4]
The role of metabolism in the pathogenesis of osteoarthritis.

Nat Rev Rheumatol. 2017-4-6

[5]
Electrical stimulation drives chondrogenesis of mesenchymal stem cells in the absence of exogenous growth factors.

Sci Rep. 2016-12-22

[6]
Effects of mechanical stress on chondrocyte phenotype and chondrocyte extracellular matrix expression.

Sci Rep. 2016-11-17

[7]
Effects of electromagnetic field exposure on conduction and concentration of voltage gated calcium channels: A Brownian dynamics study.

Brain Res. 2016-9-1

[8]
Induction of chondrogenic differentiation of human adipose-derived stem cells by low frequency electric field.

Adv Biomed Res. 2016-5-30

[9]
Calcium influx through TRP channels induced by short-lived reactive species in plasma-irradiated solution.

Sci Rep. 2016-5-12

[10]
Osteogenic Differentiation of MSC through Calcium Signaling Activation: Transcriptomics and Functional Analysis.

PLoS One. 2016-2-1

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