Piccin Andrea, Di Pierro Angela Maria, Tagnin Mario, Russo Carla, Fustos Roland, Corvetta Daisy, Primerano Marco, Magri Elena, Conci Viviana, Gentilini Ivo, Burkia Stocker Evelyn, Negri Giovanni, Mazzoleni Guido, Gastl Günther, Fontanella Fabrizio
Haematology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy.
Interdisciplinary Medical Research Center (IMREST), Bolzano, South Tyrol, Italy.
Regen Med. 2016 Jul;11(5):459-63. doi: 10.2217/rme-2016-0031. Epub 2016 Jun 27.
Bone osteoradionecrosis is a serious complication of radiation treatment. Current treatment approaches are not curative and treatment response is often poor leading to high social and healthcare costs.
We report on the first case of osteoradionecrosis with successful restitutio ab integro by repeated administration of platelet gel (PLT-gel) and surgery in a critically ill patient. The administration of PLT-gel during a severe septic episode helped regeneration of bone and soft tissues, shortening the hospital stay of the patient. It was also noted that following applications of PLT-gel, both the use of morphine and the numbers of infective episodes were reduced.
Additional studies are needed to confirm the promising effect of PLT-gel for the treatment of osteoradionecrosis.
骨放射性坏死是放射治疗的一种严重并发症。目前的治疗方法无法治愈，治疗反应往往不佳，导致高昂的社会和医疗成本。
我们报告了首例在一名重症患者中通过反复应用血小板凝胶（PLT-凝胶）和手术成功实现完全康复的骨放射性坏死病例。在严重脓毒症发作期间应用PLT-凝胶有助于骨和软组织的再生，缩短了患者的住院时间。还注意到，在应用PLT-凝胶后，吗啡的使用量和感染发作次数均有所减少。
需要进一步研究以证实PLT-凝胶治疗骨放射性坏死的显著效果。
