Bloom K R, Bini R M, Williams C M, Sonley M J, Gribbin M A
Cancer. 1978 Apr;41(4):1265-9. doi: 10.1002/1097-0142(197804)41:4<1265::aid-cncr2820410408>3.0.co;2-r.
Twenty-six patients receiving adriamycin for osteogenic sarcoma had serial echocardiographic assessments of their left ventricular function. A statistically significant deterioration of function was noted throughout the course. Ventricular function tended to normalize in the period following cessation of adriamycin. The velocity of circumferential fibre shortening (Vcf) and ejection fraction (EF) were the best parameters. Sudden declines in these values resulted in us withholding therapy until the parameters again improved. Fatal congestive heart failure was seen in only one patient. Echocardiography thus provides the clinician with a valuable tool enabling one to improve the therapeutic usefulness of adriamycin by removing much of the uncertainty over the development of cardiotoxicity.
26名接受阿霉素治疗骨肉瘤的患者接受了左心室功能的系列超声心动图评估。在整个疗程中均观察到功能有统计学意义的恶化。在阿霉素停药后的一段时间内，心室功能趋于正常。圆周纤维缩短速度（Vcf）和射血分数（EF）是最佳参数。这些值的突然下降导致我们暂停治疗，直到参数再次改善。仅1例患者出现致命性充血性心力衰竭。因此，超声心动图为临床医生提供了一种有价值的工具，通过消除心脏毒性发生过程中的许多不确定性，能够提高阿霉素的治疗效用。
