Baltzis Dimitrios, Bakker Jessie P, Patel Sanjay R, Veves Aristidis
Microcirculation Lab and Joslin-Beth Israel Deaconess Foot Center, Harvard Medical School, Boston, USA.
Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Compr Physiol. 2016 Jun 13;6(3):1519-28. doi: 10.1002/cphy.c150029.
Obstructive sleep apnea (OSA) affects a large proportion of adults, and is as an independent risk factor for cerebrovascular and cardiovascular disease. The repetitive airway obstruction that characterizes OSA results in intermittent hypoxia, intrathoracic pressure swings, and sleep fragmentation, which in turn lead to sympathetic activation, oxidative stress, inflammation, and endothelial dysfunction. This review outlines the associations between OSA and vascular diseases and describes basic mechanisms that may be responsible for this association, in both the micro- and macrocirculation. It also reports on interventional studies that aim to ameliorate OSA and thereby reduce vascular disease burden. © 2016 American Physiological Society. Compr Physiol 6:1519-1528, 2016.
阻塞性睡眠呼吸暂停（OSA）影响着很大一部分成年人，并且是脑血管和心血管疾病的独立危险因素。OSA的特征性反复气道阻塞会导致间歇性缺氧、胸内压力波动和睡眠片段化，进而导致交感神经激活、氧化应激、炎症和内皮功能障碍。本综述概述了OSA与血管疾病之间的关联，并描述了在微循环和大循环中可能导致这种关联的基本机制。它还报告了旨在改善OSA从而减轻血管疾病负担的干预性研究。© 2016美国生理学会。《综合生理学》6:1519 - 1528, 2016年。
