寨卡病毒感染与神经发病机制
Mechanisms of Zika Virus Infection and Neuropathogenesis.
作者信息
Olagnier David, Muscolini Michela, Coyne Carolyn B, Diamond Michael S, Hiscott John
机构信息
1 Lady Davis Institute, Jewish General Hospital, McGill University , Montreal, Canada .
2 Istituto Pasteur-Fondazione Cenci Bolognetti , Rome, Italy .
出版信息
DNA Cell Biol. 2016 Aug;35(8):367-72. doi: 10.1089/dna.2016.3404. Epub 2016 Jun 27.
Abstract
A spotlight has been focused on the mosquito-borne Zika virus (ZIKV) because of its epidemic outbreak in Brazil and Latin America, as well as the severe neurological manifestations of microcephaly and Guillain-Barré syndrome associated with infection. In this review, we discuss the recent literature on ZIKV-host interactions, including new mechanistic insight concerning the basis of ZIKV-induced neuropathogenesis.
摘要
由于寨卡病毒（ZIKV）在巴西和拉丁美洲的爆发流行，以及与感染相关的小头畸形和吉兰 - 巴雷综合征等严重神经表现，这种蚊媒病毒已成为焦点。在本综述中，我们讨论了关于ZIKV与宿主相互作用的最新文献，包括有关ZIKV诱导神经发病机制基础的新机制见解。
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