肠道微生物群与造血干细胞移植：我们目前的进展如何？
Gut microbiota and hematopoietic stem cell transplantation: where do we stand?
作者信息
Zama D, Biagi E, Masetti R, Gasperini P, Prete A, Candela M, Brigidi P, Pession A
机构信息
Pediatric Oncology and Haematology Unit 'Lalla Seràgnoli', Department of Pediatrics, University of Bologna, Sant'Orsola Malpighi Hospital, Bologna, Italy.
Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
出版信息
Bone Marrow Transplant. 2017 Jan;52(1):7-14. doi: 10.1038/bmt.2016.173. Epub 2016 Jun 27.
Advances in biological techniques have potentiated great progresses in understanding the interaction between human beings and the ∼10 to 100 trillion microbes living in their gastrointestinal tract: gut microbiota (GM). In this review, we describe recent emerging data on the role of GM in hematopoietic stem cell transplantation, with a focus on immunomodulatory properties in the immune system recovery and the impact in the development of the main complications, as GvHD and infections.
生物技术的进步促进了在理解人类与生活在其胃肠道中的约10万亿至100万亿微生物（即肠道微生物群，GM）之间相互作用方面取得了巨大进展。在这篇综述中，我们描述了关于GM在造血干细胞移植中作用的最新数据，重点关注其在免疫系统恢复中的免疫调节特性以及对主要并发症（如移植物抗宿主病和感染）发展的影响。
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