Riyaz Ambreena, Nazir Shahid, Khushtar Mohammad, Mishra Anuradha, Jahan Yasmeen, Ahmad Asad
a Faculty of Pharmacy , Integral University , Lucknow , India.
b School of Veterinary Medicine , Wollo University , Dessie , Ethiopia.
Nat Prod Res. 2017 Mar;31(5):588-592. doi: 10.1080/14786419.2016.1201670. Epub 2016 Jun 27.
The aim of this study was focused on investigating the possible protective effect of Nigella sativa L. seed extract against cisplatin-induced delay in gastric emptying, in a rat model. Twenty-five male Sprague-Dawley rats were divided into five equal groups as follows: Group I or control group, Group II (cisplatin 10 mg/kg, i.p at day 5), Group III (N. sativa L. 250 mg/kg for 5 days + cisplatin 10 mg/kg, i.p on day 5), Group IV (N. sativa L. 500 mg/kg for 5 days + cisplatin 10 mg/kg, i.p on day 5) and Group V (ondansetron 3 mg/kg/day, per os + cisplatin 10 mg/kg, i.p on day 5). Phenol red meal was adopted to estimate gastric emptying in different groups of the rats. Gastric emptying was significantly increased (p < 0.01) in N. sativa L. seed extract-pretreated rats (Group III and Group IV) when compared to cisplatin treatment alone (Group II). However, ondansetron produced significantly (p < 0.01) better reversal than N. sativa L. seed extract.
本研究旨在探讨黑种草籽提取物对顺铂诱导的大鼠胃排空延迟的可能保护作用。将25只雄性Sprague-Dawley大鼠分为五组，每组五只：第一组或对照组；第二组（第5天腹腔注射顺铂10mg/kg）；第三组（连续5天每天灌胃黑种草籽250mg/kg + 第5天腹腔注射顺铂10mg/kg）；第四组（连续5天每天灌胃黑种草籽500mg/kg + 第5天腹腔注射顺铂10mg/kg）；第五组（每天口服昂丹司琼3mg/kg + 第5天腹腔注射顺铂10mg/kg）。采用酚红餐法评估不同组大鼠的胃排空情况。与单独使用顺铂治疗的第二组相比，黑种草籽提取物预处理的大鼠（第三组和第四组）胃排空显著增加（p < 0.01）。然而，昂丹司琼产生的逆转效果明显优于黑种草籽提取物（p < 0.01）。
