钯与光氧化还原催化融合实现酰胺的有氧氧化羰基化反应。
Aerobic Oxidative Carbonylation of Enamides by Merging Palladium with Photoredox Catalysis.
机构信息
College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University , Wuhan 430072, China.
State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou 730000, China.
出版信息
J Org Chem. 2016 Aug 19;81(16):7088-92. doi: 10.1021/acs.joc.6b00965. Epub 2016 Jul 14.
Intramolecular oxidative carbonylation reaction is an efficient approach for constructing heterocycles. However, stoichiometric amount of hypervalent metal salts is usually required in this transformation. Here we show an aerobic intramolecular oxidative carbonylation of enamides by combining palladium and photoredox catalysis. The dual catalytic system enables oxygen directly as oxidant, which provides a mild and environmentally friendly method for the synthesis of 1,3-oxazin-6-ones.
分子内氧化羰基化反应是构建杂环的一种有效方法。然而，这种转化通常需要化学计量的高价金属盐。在这里，我们展示了钯和光氧化还原催化相结合的烯酰胺的有氧分子内氧化羰基化反应。双催化体系使氧气能够直接作为氧化剂，为 1,3-恶嗪-6-酮的合成提供了一种温和环保的方法。
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